Fusarium wilt is an economically important disease of cotton in Australia. Disease occurs at the intersection of pathogen, plant, and environment (Figure I). In the case of Fusarium wilt, the disease can only occur when cotton (the plant), infected by the soil-borne fungus Fusarium oxysporum vasinfectum (Fov) (the pathogen), experiences environmental conditions that favour the pathogen above the plant. Current control measures are by and large focussed on limiting the spread of the pathogen, and developing new cotton varieties with increased resistance to the disease